Amiodarone with digoxin

Nov 6, 2016. The amiodarone digoxin interaction is one that every pharmacist should know. Here's what to expect along with a few other clinical pearls. Amiodarone-digoxin interaction: clinical significance, time course of development , potential pharmacokinetic mechanisms and therapeutic implications. Amiodarone is known to raise serum digoxin levels. This study was designed to evaluate the pharmacokinetic basis of this interaction in 10 normal subjects. Before taking amiodarone, tell your doctor if you also use digoxin. You may need dose adjustments or special tests in order to safely take both medications . Amiodarone-digoxin interaction: clinical significance, time course of development , potential pharmacokinetic mechanisms and therapeutic implications. Administration of amiodarone (600 to 1,600 mg/day) to. 28 patients during longterm digoxin therapy (0.25 ±. 0.05 mglday) increased serum digoxin level from . Twenty-two patients were given amiodarone for refractory cardiac arrhythmias, and preand post-amiodarone serum digoxin levels were studied. The interval . The coadministration of amiodarone and digoxin can increase the serum concentrations of digoxin and the risk for digoxin toxicity. Dec 1, 2003. When long-term amiodarone therapy is used, potential drug toxicity and. In patients who also are taking digoxin and warfarin, physicians must ..